The RisC study is trying to understand more about the genetic variants that contribute to inherited cancer.
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Genes are made of DNA – the chemical structure carrying your genetic information that determines many human characteristics. Researchers study genes in order to understand why some people have a certain condition such as cancer and why some people do not. We all have approximately 20 000 genes. This is called our genome. Cancer is caused by alterations (variants) in our genes that make cells grow out of control and spread abnormally. Some, but not all, genetic variants that increase the risk of developing cancer are inherited (passed on from parent to child) and have implications for all blood relatives. We already know about some of these, but there is still much more to learn. Whole genome sequencing involves obtaining the sequence of all of your 20 000 genes in one test. The RisC study is trying to understand more about the genetic variants that contribute to inherited cancer. This is important for people with cancer and their families. We hope that this knowledge will lead to more personalised cancer treatments with better outcomes, improved cancer screening, increased options for reducing cancer risks and more fully informed lifestyle and reproductive decisions. We aim to also assess health related costs. Who can participate in RisC? Patients diagnosed with a cancerless than 40 years of age, patients diagnosed with 2 different cancer less than 50 years of age or 3 or more cancers over the age of 50 years. What does participation involve? - Discussing the study with the RisC team(telephone or face to face) - Consenting to access to samples held by pathology centres - Consenting to access to medical and similar records - Donating a blood sample - Supplying family history information - Completing questionnaires - Consenting to biobanking (optional)